Home > Projects > Informatics > Universal Browser

Informatics


Universal Browser > enter Universal Browser

 

------------------------------------------------------------------------------------------

UB User Survey

We are currently conducting a survey into the use and benefits of the Universal Browser. The short survey includes 14 questions and allows users to provide feedback which will be used for future developments of the application. Enter survey here >>

------------------------------------------------------------------------------------------

 

NGRL Manchester developed the Universal Browser to display variant information graphically on a DNA sequence. Other sources of variant data lacked good graphical displays, and rarely annotate variant data according to the standards used in diagnostic laboratories (HGVS nomenclature). This makes collection and comparison of data from different sources difficult for laboratory users, something that clinical scientists often wish to do this when analysing a variant. We therefore developed the UB as a common tool for variant display. It was designed to allowed tabulated as well as graphical displays of variant data, as this makes searching and comparison easier, and to allow data from multiple databases to be displayed alongside each other. The UB is used by many as the main method for searching DMuDB.

 

We are working to cover all the genes on the UK Genetic Testing Network (UKGTN) website by the browser. Variant data from dbSNP, the Breast Cancer Information Core Database (BIC), DMuDB and now the MMR Genes Variant Database are accessible in HGVS format.

 

The last major update of the Browser was carried out in November, 2009. This brought the data on display up-to-date with human genome build 37 and dbSNP build 130. More than 164,000 variants are now browsable across 351 genes and 18 variant databases.

 

We are currently working with the creators of the Leiden Open Variant Database
(LOVD) to provide the ability to browse the data held in databases implemented using that system.

 

We welcome suggestions from users for the integration of new genes or databases which they would like to be made available in the Universal browser. Please contact us with any such requests.